[Oral Presentation]基于MP-PIC方法的干粉吸入装置内颗粒分散行为的研究

Organized By

Hohai University

Monash University

Co-organized by

Southeast University

Jiangxi University of Science and Technology

Northeast University

DUT-BSU Scientific Research and Innovation Center

Suzhou University of Science and Technology

State Key Laboratory of Structural Analysis, Optimization and CAE Software for Industrial Equipment

Sponsoring agency

KELI SDEM Software (Dalian) Co., Ltd.

Sugon Smart Computing Information Technology Co., Ltd.

Beijing Paratera Technology Co., Ltd.

Simpop Information Technology Co., Ltd.

Important Dates

Conference Announcement

December 2023, release First Round Announcement
Abstract Submission Deadline
March 31^th, 2024
Paper Submission Deadline
April 30^th, 2024
Registration
From January 1^st, 2024
Conference Schedule
May 31^st (Friday), 2024 On-Site Registration
June 1^st to 3^rd, 2024 Conference

基于MP-PIC方法的干粉吸入装置内颗粒分散行为的研究

ID：45 Submission ID：136 View Protection：ATTENDEE Updated Time：2024-04-09 22:08:28 Hits：411 Oral Presentation

Start Time：Pending （Asia/Shanghai）

Duration：Pending

Session：[No Session] » [No Session Block]

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Abstract

干粉吸入器（DPI）的药物递送是受气流和颗粒碰撞等多个因素影响的复杂过程，其中基于载体颗粒的二元制剂的性能取决于活性药物成分（API）颗粒的释放。目前干粉吸入装置内颗粒流化行为通常使用DEM方法计算，但其计算成本较高，不适用于大规模颗粒运算。MP-PIC方法由于能够通过欧拉网格的应力梯度计算碰撞力，并将真实粒子打包为计算粒子，显著提高了计算效率。本文基于该方法建立了DPI三维全场气固流动的数理模型，考虑了格栅、颗粒团聚体、球形度效应等，研究了微米级颗粒在DPI模型中的剂量排空和分散行为，评估了不同粒径的载体颗粒的配方设计。结果表明，装置内颗粒分散性能随着载体颗粒直径的增加而减弱，干粉吸入器内药物粉末残留量逐渐变多。本方法能较好地捕捉到干粉吸入器中的颗粒流化行为，为DPI模型中颗粒分散行为提供了一种有前景的预测方法。

Keywords

颗粒材料；计算力学；MP-PIC；干粉吸入器

Speaker

徐昊

南京师范大学

Submission Author

徐昊南京师范大学

谢俊南京师范大学

Sponsored By

Hohai University

Panel of Computational Mechanics on Granular Materials, Working Party of Computational Mechanics, Chinese Society of Theoretical and Applied Mechanics

Jiangsu Society of Theoretical and Applied Mechanics