[Oral Presentation]片剂包衣过程离散元仿真方法研究

Organized By

Hohai University

Monash University

Co-organized by

Southeast University

Jiangxi University of Science and Technology

Northeast University

DUT-BSU Scientific Research and Innovation Center

Suzhou University of Science and Technology

State Key Laboratory of Structural Analysis, Optimization and CAE Software for Industrial Equipment

Sponsoring agency

KELI SDEM Software (Dalian) Co., Ltd.

Sugon Smart Computing Information Technology Co., Ltd.

Beijing Paratera Technology Co., Ltd.

Simpop Information Technology Co., Ltd.

Important Dates

Conference Announcement

December 2023, release First Round Announcement
Abstract Submission Deadline
March 31^th, 2024
Paper Submission Deadline
April 30^th, 2024
Registration
From January 1^st, 2024
Conference Schedule
May 31^st (Friday), 2024 On-Site Registration
June 1^st to 3^rd, 2024 Conference

片剂包衣过程离散元仿真方法研究

ID：26 Submission ID：56 View Protection：ATTENDEE Updated Time：2024-04-09 22:00:53 Hits：493 Oral Presentation

Start Time：Pending （Asia/Shanghai）

Duration：Pending

Session：[No Session] » [No Session Block]

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Abstract

在制药业中，包衣是一种对片剂产品质量影响重大的涂层技术，良好的片剂包衣能够满足外观美观、药物释放可控、稳定性好、口感好等多个方面的要求。开展片剂包衣过程的离散元数值模拟研究，有助于加强对设备结构、工艺参数、药物剂型与最终产品质量之间关系的理解，对于优化包衣工艺、提升片剂质量具有重要意义。在本研究中，通过组合超椭球模型对复杂片剂进行精准建模，并提出了基于组合超椭球模型的DEM-DDM 数值仿真方法对片剂间包衣均匀度进行预测。在此基础上，结合颗粒表面网格划分方法，实现包衣过程中单片剂均匀度的仿真计算。最终，通过本研究提出的包衣仿真方法，分析了颗粒形状、包衣参数等对片剂运动行为、片剂间包衣均匀度与单片剂包衣均匀度的影响。

Keywords

计算颗粒力学,离散单元法,离散液滴模型,片剂包衣,组合超椭球模型

Speaker

刘子寒

浙江大学能源工程学院化工机械研究所

Submission Author

刘子寒浙江大学能源工程学院化工机械研究所

赵永志浙江大学

Sponsored By

Hohai University

Panel of Computational Mechanics on Granular Materials, Working Party of Computational Mechanics, Chinese Society of Theoretical and Applied Mechanics

Jiangsu Society of Theoretical and Applied Mechanics